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Creation of chimeric human/rabbit APOBEC1 with HIV-1 restriction and DNA mutation activities
APOBEC1 (A1) proteins from lagomorphs and rodents have deaminase-dependent restriction activity against HIV-1, whereas human A1 exerts a negligible effect. To investigate these differences in the restriction of HIV-1 by A1 proteins, a series of chimeric proteins combining rabbit and human A1s was co...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4704027/ https://ncbi.nlm.nih.gov/pubmed/26738439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19035 |
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