Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one

The infectivity and persistence of Mycobacterium tuberculosis requires the utilization of host cell cholesterol. We have examined the specific role of cytochrome P450 CYP125A1 in the cholesterol degradation pathway using genetic, biochemical, and high resolution mass spectrometric approaches. The an...

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Autors principals: Ouellet, Hugues, Guan, Shenheng, Johnston, Jonathan B., Chow, Eric D., Kells, Petrea M., Burlingame, Alma L., Cox, Jeffery S., Podust, Larissa M., Ortiz de Montellano, Paul R.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909382/
https://ncbi.nlm.nih.gov/pubmed/20545858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2010.07243.x
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