REVERSE TYPE I INHIBITOR OF MYCOBACTERIUM TUBERCULOSIS CYP125A1

Cytochrome P450 CYP125A1 of Mycobacterium tuberculosis, a potential therapeutic target for tuberculosis in humans, initiates degradation of the aliphatic chain of host cholesterol and is essential for establishing M. tuberculosis infection in a mouse model of disease. We explored the interactions of...

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Bibliographic Details
Main Authors: Ouellet, Hugues, Kells, Petrea M., Ortiz de Montellano, Paul R., Podust, Larissa M.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3011832/
https://ncbi.nlm.nih.gov/pubmed/21109436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.11.007
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