Themis is a member of a new metazoan gene family and is required for completion of thymocyte positive selection

T-cell receptor signaling in CD4(+)CD8(+) double positive thymocytes determines cell survival and lineage commitment, but the genetic and molecular basis of this process is poorly defined. To address this issue, we used ethylnitrosourea mutagenesis to identify a novel T-lineage-specific gene, Themis...

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Bibliografiske detaljer
Main Authors: Johnson, Andy L., Aravind, L., Shulzhenko, Natalia, Morgun, Andriy, Choi, See-Young, Crockford, Tanya L., Lambe, Teresa, Domaschenz, Heather, Kucharska, Edyta, Zheng, Lixin, Vinuesa, Carola C., Lenardo, Michael J., Goodnow, Christopher C., Cornall, Richard J., Schwartz, Ronald H.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908989/
https://ncbi.nlm.nih.gov/pubmed/19597497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1769
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