Themis is a member of a new metazoan gene family and is required for completion of thymocyte positive selection

T-cell receptor signaling in CD4(+)CD8(+) double positive thymocytes determines cell survival and lineage commitment, but the genetic and molecular basis of this process is poorly defined. To address this issue, we used ethylnitrosourea mutagenesis to identify a novel T-lineage-specific gene, Themis...

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Detalhes bibliográficos
Main Authors: Johnson, Andy L., Aravind, L., Shulzhenko, Natalia, Morgun, Andriy, Choi, See-Young, Crockford, Tanya L., Lambe, Teresa, Domaschenz, Heather, Kucharska, Edyta, Zheng, Lixin, Vinuesa, Carola C., Lenardo, Michael J., Goodnow, Christopher C., Cornall, Richard J., Schwartz, Ronald H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908989/
https://ncbi.nlm.nih.gov/pubmed/19597497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1769
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