Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function

Themis1, a recently identified T cell protein, has a critical function in the generation of mature CD4(+)CD8(−) and CD4(−)CD8(+) (CD4- and CD8- single positive; SP) thymocytes and T cells. Although Themis1 has been shown to bind to the adapter proteins LAT and Grb2, previous studies have yielded con...

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Detalhes bibliográficos
Principais autores: Lesourne, Renaud, Zvezdova, Ekaterina, Song, Ki-Duk, El-Khoury, Dalal, Uehara, Shoji, Barr, Valarie A., Samelson, Lawrence E., Love, Paul E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401357/
https://ncbi.nlm.nih.gov/pubmed/22732588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200123
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