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Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease
Negative selection and regulatory T (T reg) cell development are two thymus-dependent processes necessary for the enforcement of self-tolerance, and both require high-affinity interactions between the T cell receptor (TCR) and self-ligands. However, it remains unclear if they are similarly impacted...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3457736/ https://ncbi.nlm.nih.gov/pubmed/22945921 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20120058 |
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