THEMIS enhances TCR signaling and enables positive selection by selective inhibition of SHP-1

THEMIS, a T cell specific protein that is highly expressed in CD4(+)CD8(+) thymocytes, has a crucial role in positive selection and T cell development. THEMIS lacks defined catalytic domains but contains two tandem repeats of a distinctive (CABIT) module of unknown function. Here, we show that THEMI...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nat Immunol
Päätekijät: Choi, Seeyoung, Warzecha, Claude, Zvezdova, Ekaterina, Lee, Jan, Argenty, Jérémy, Lesourne, Renaud, Aravind, L., Love, Paul E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807080/
https://ncbi.nlm.nih.gov/pubmed/28250424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3692
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia