THEMIS enhances TCR signaling and enables positive selection by selective inhibition of SHP-1

THEMIS, a T cell specific protein that is highly expressed in CD4(+)CD8(+) thymocytes, has a crucial role in positive selection and T cell development. THEMIS lacks defined catalytic domains but contains two tandem repeats of a distinctive (CABIT) module of unknown function. Here, we show that THEMI...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Immunol
Prif Awduron: Choi, Seeyoung, Warzecha, Claude, Zvezdova, Ekaterina, Lee, Jan, Argenty, Jérémy, Lesourne, Renaud, Aravind, L., Love, Paul E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5807080/
https://ncbi.nlm.nih.gov/pubmed/28250424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3692
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