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THEMIS enhances TCR signaling and enables positive selection by selective inhibition of SHP-1
THEMIS, a T cell specific protein that is highly expressed in CD4(+)CD8(+) thymocytes, has a crucial role in positive selection and T cell development. THEMIS lacks defined catalytic domains but contains two tandem repeats of a distinctive (CABIT) module of unknown function. Here, we show that THEMI...
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| Publicat a: | Nat Immunol |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5807080/ https://ncbi.nlm.nih.gov/pubmed/28250424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3692 |
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