DOCK8 mutations cripple B cell immune synapse, germinal centers and long-lived antibody production

To illuminate genes and mechanisms for humoral immunity we performed a mouse genetic screen for mutations that do not affect the first wave of antibody to immunization but disrupt response maturation and persistence. The first two mutants identified were loss-of-function mutations in DOCK8. DOCK8 mu...

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Библиографические подробности
Главные авторы: Randall, Katrina L., Lambe, Teresa, Johnson, Andy L., Treanor, Bebhinn, Kucharska, Edyta, Domaschenz, Heather, Whittle, Belinda, Tze, Lina E., Enders, Anselm, Crockford, Tanya L., Bouriez-Jones, Tiphaine, Alston, Duncan, Cyster, Jason G., Lenardo, Michael J., Mackay, Fabienne, Deenick, Elissa K., Tangye, Stuart G., Chan, Tyani D., Camidge, Tahra, Brink, Robert, Vinuesa, Carola G., Batista, Facundo D., Cornall, Richard J., Goodnow, Christopher C.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437189/
https://ncbi.nlm.nih.gov/pubmed/19898472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1820
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