DOCK8 mutations cripple B cell immune synapse, germinal centers and long-lived antibody production

To illuminate genes and mechanisms for humoral immunity we performed a mouse genetic screen for mutations that do not affect the first wave of antibody to immunization but disrupt response maturation and persistence. The first two mutants identified were loss-of-function mutations in DOCK8. DOCK8 mu...

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Autori principali: Randall, Katrina L., Lambe, Teresa, Johnson, Andy L., Treanor, Bebhinn, Kucharska, Edyta, Domaschenz, Heather, Whittle, Belinda, Tze, Lina E., Enders, Anselm, Crockford, Tanya L., Bouriez-Jones, Tiphaine, Alston, Duncan, Cyster, Jason G., Lenardo, Michael J., Mackay, Fabienne, Deenick, Elissa K., Tangye, Stuart G., Chan, Tyani D., Camidge, Tahra, Brink, Robert, Vinuesa, Carola G., Batista, Facundo D., Cornall, Richard J., Goodnow, Christopher C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437189/
https://ncbi.nlm.nih.gov/pubmed/19898472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1820
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