טוען...
DOCK8 mutations cripple B cell immune synapse, germinal centers and long-lived antibody production
To illuminate genes and mechanisms for humoral immunity we performed a mouse genetic screen for mutations that do not affect the first wave of antibody to immunization but disrupt response maturation and persistence. The first two mutants identified were loss-of-function mutations in DOCK8. DOCK8 mu...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2009
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| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3437189/ https://ncbi.nlm.nih.gov/pubmed/19898472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1820 |
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