GRB2-Mediated Recruitment of THEMIS to LAT Is Essential for Thymocyte Development

Thymocyte-expressed molecule involved in selection (THEMIS) is a recently identified regulator of thymocyte positive selection. THEMIS’s mechanism of action is unknown, and whether it has a role in TCR-proximal signaling is controversial. In this article, we show that THEMIS and the adapter molecule...

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Autores principales: Paster, Wolfgang, Brockmeyer, Claudia, Fu, Guo, Simister, Philip C., de Wet, Ben, Martinez-Riaño, Ana, Hoerter, John A. H., Feller, Stephan M., Wülfing, Christoph, Gascoigne, Nicholas R. J., Acuto, Oreste
Formato: Artigo
Lenguaje:Inglês
Publicado: AAI 2013
Materias:
Molecular and Structural Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607403/
https://ncbi.nlm.nih.gov/pubmed/23460737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203389
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