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Allosteric modulation of Grb2 recruitment to the intrinsically disordered scaffold protein, LAT, by remote site phosphorylation

Tyrosine phosphorylation of membrane receptors and scaffold proteins followed by recruitment of SH2 domain-containing adaptor proteins constitutes a central mechanism of intracellular signal transduction. During early T-cell receptor (TCR) activation, phosphorylation of Linker for Activation of T ce...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Huang, William Y. C., Ditlev, Jonathon A., Chiang, Han-Kuei, Rosen, Michael K., Groves, Jay T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5761276/
https://ncbi.nlm.nih.gov/pubmed/29182244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b09387
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