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A Hotspot of Inactivation: The A22S and V108M Polymorphisms Individually Destabilize the Active Site Structure of Catechol O-Methyltransferase
Human catechol O-methyltransferase (COMT) contains three common polymorphisms (A22S, A52T, V108M), two of which (A22S, V108M) render the protein susceptible to deactivation by temperature or oxidation. We have performed multiple molecular dynamics simulations of the wild-type, A22S, A52T, and V108M...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2906713/ https://ncbi.nlm.nih.gov/pubmed/19435324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900174v |
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