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The Histamine N-Methyltransferase T105I Polymorphism Affects Active Site Structure and Dynamics
Histamine N-methyltransferase (HNMT) is the sole enzyme responsible for inactivating histamine in the mammalian brain. The human HNMT gene contains a common threonine-isoleucine polymorphism at residue 105, distal from the active site. The 105I variant has decreased activity and lower protein levels...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2905460/ https://ncbi.nlm.nih.gov/pubmed/18154359 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi701737f |
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