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The V119I polymorphism in protein L-isoaspartate O-methyltransferase alters the substrate-binding interface
Protein L-isoaspartate O-methyltransferase (PIMT) repairs isoaspartate residues in damaged proteins, and it contains a Val–Ile polymorphismin in α5, ∼13 Å from its active site. Val119 has lower activity and thermal stability but increased affinity for endogenous substrates. Studies suggest that hete...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Oxford University Press
2009
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2777021/ https://ncbi.nlm.nih.gov/pubmed/19801578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzp056 |
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