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Functional divergence of annotated l-isoaspartate O-methyltransferases in an α-proteobacterium

Spontaneous formation of isoaspartates (isoDs) often causes protein damage. l-Isoaspartate O-methyltransferase (PIMT) repairs isoD residues by catalyzing the formation of an unstable l-isoaspartyl methyl ester that spontaneously converts to an l-aspartyl residue. PIMTs are widely distributed in all...

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Pubblicato in:J Biol Chem
Autore principale: Harwood, Caroline S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6393607/
https://ncbi.nlm.nih.gov/pubmed/30578298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006546
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