Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112

The protein tyrosine phosphatase (PTP) Shp2 (PTPN11) is an attractive target for anticancer drug discovery because it mediates growth factor signaling and its gain-of-function mutants are causally linked to leukemias. We previously synthesized SPI-112 from a lead compound of Shp2 inhibitor, NSC-1171...

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Autores principales: Chen, Liwei, Pernazza, Daniele, Scott, Latanya M., Lawrence, Harshani R., Ren, Yuan, Luo, Yunting, Wu, Xin, Sung, Shen-Shu, Guida, Wayne C., Sebti, Said M., Lawrence, Nicholas J., Wu, Jie
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906681/
https://ncbi.nlm.nih.gov/pubmed/20510203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2010.05.019
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