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Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112
The protein tyrosine phosphatase (PTP) Shp2 (PTPN11) is an attractive target for anticancer drug discovery because it mediates growth factor signaling and its gain-of-function mutants are causally linked to leukemias. We previously synthesized SPI-112 from a lead compound of Shp2 inhibitor, NSC-1171...
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| Hlavní autoři: | , , , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2906681/ https://ncbi.nlm.nih.gov/pubmed/20510203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2010.05.019 |
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