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Enhanced anti-melanoma efficacy of interferon alfa-2b via inhibition of Shp2
Interferon-α2b (IFN-α2b) is used to treat melanoma but there is a need to improve its efficacy. IFN-α2b signaling requires STAT1/STAT2 tyrosine phosphorylation and is subject to negative regulation by phosphatases. In this study, we determined whether inhibition of the protein tyrosine phosphatase S...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3319810/ https://ncbi.nlm.nih.gov/pubmed/22306001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2012.01.034 |
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