Inhibition of Shp2 suppresses mutant EGFR-induced lung tumors in transgenic mouse model of lung adenocarcinoma

Epidermal growth factor receptor (EGFR) mutants drive lung tumorigenesis and are targeted for therapy. However, resistance to EGFR inhibitors has been observed, in which the mutant EGFR remains active. Thus, it is important to uncover mediators of EGFR mutant-driven lung tumors to develop new treatm...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Schneeberger, Valentina E., Ren, Yuan, Luetteke, Noreen, Huang, Qingling, Chen, Liwei, Lawrence, Harshani R., Lawrence, Nicholas J., Haura, Eric B., Koomen, John M., Coppola, Domenico, Wu, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467431/
https://ncbi.nlm.nih.gov/pubmed/25730908
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