SHP2(E76K) mutant promotes lung tumorigenesis in transgenic mice

Lung cancer is a major disease carrying heterogeneous molecular lesions and many of them remain to be analyzed functionally in vivo. Gain-of-function (GOF) SHP2 (PTPN11) mutations have been found in various types of human cancer, including lung cancer. However, the role of activating SHP2 mutants in...

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Main Authors: Schneeberger, Valentina E., Luetteke, Noreen, Ren, Yuan, Berns, Hartmut, Chen, Liwei, Foroutan, Parastou, Martinez, Gary V., Haura, Eric B., Chen, Jiandong, Coppola, Domenico, Wu, Jie
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
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Original Manuscript
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123642/
https://ncbi.nlm.nih.gov/pubmed/24480804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgu025
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