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NMR-based design and evaluation of novel bidentate inhibitors of the protein tyrosine phosphatase YopH
We describe the use of a furanyl salicyl nitroxide derivative (“spin-labeled” compound), as a paramagnetic phosphotyrosine mimetic, to carry out a second-site screening by NMR against the PTPase YopH from Yersinia pestis. Using such a fragment-based screening approach we identified several small mol...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2905849/ https://ncbi.nlm.nih.gov/pubmed/20456369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2010.00982.x |
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