NMR-based design and evaluation of novel bidentate inhibitors of the protein tyrosine phosphatase YopH

We describe the use of a furanyl salicyl nitroxide derivative (“spin-labeled” compound), as a paramagnetic phosphotyrosine mimetic, to carry out a second-site screening by NMR against the PTPase YopH from Yersinia pestis. Using such a fragment-based screening approach we identified several small mol...

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Detaylı Bibliyografya
Asıl Yazarlar: Leone, Marilisa, Barile, Elisa, Vazquez, Jesus, Mei, Angel, Guiney, Donald, Dahl, Russel, Pellecchia, Maurizio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905849/
https://ncbi.nlm.nih.gov/pubmed/20456369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2010.00982.x
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