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Light-Induced Isomerization of Apoptolidin A leads to Inversion of C2-C3 Double Bond Geometry

[Image: see text] The isolation, characterization and cytotoxicity against H292 cells of apoptolidin G are reported. Apoptolidin G is shown to be derived by a light-induced isomerization of the C2-C3 carbon-carbon double bond of apoptolidin A.

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Detalhes bibliográficos
Main Authors: Bachmann, Brian O., McNees, Ruth, Melancon, Bruce J., Ghidu, Victor P., Clark, Rachel, Crews, Brenda C., DeGuire, Sean M., Marnett, Lawrence J., Sulikowski, Gary A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905629/
https://ncbi.nlm.nih.gov/pubmed/20515014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol1009398
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