The Use of Fluorescently Tagged Apoptolidins in Cellular Uptake and Response Studies

The apoptolidins are glycomacrolide microbial metabolites reported to be selectively cytotoxic against tumor cells. Using fluorescently tagged active derivatives we demonstrate selective uptake of these tagged glycomacrolides in cancer cells over healthy human blood cells. We also demonstrate the ut...

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Pubblicato in:J Antibiot (Tokyo)
Autori principali: Chong, Katherine M., Leelatian, Nalin, Deguire, Sean M., Brockman, Asa A., Earl, David, Ihrie, Rebecca A., Irish, Jonathan M., Bachmann, Brian O., Sulikowski, Gary A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518790/
https://ncbi.nlm.nih.gov/pubmed/26956792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ja.2016.22
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