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Biosynthesis of the Apoptolidins in Nocardiopsis sp. FU 40

The apoptolidins are 20/21-membered macrolides produced by Nocardiopsis sp. FU40. Several members of this family are potent and remarkably selective inducers of apoptosis in cancer cell lines, likely via a distinct mitochondria associated target. To investigate the biosynthesis of this natural produ...

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Autori principali: Du, Yu, Derewacz, Dagmara K., Deguire, Sean M., Teske, Jesse, Ravel, Jacques, Sulikowski, Gary A., Bachmann, Brian O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159176/
https://ncbi.nlm.nih.gov/pubmed/21869849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2011.05.106
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