Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis

Pre-rRNA transcription by RNA Polymerase I (Pol I) is very robust on active rDNA repeats. Loss of yeast Topoisomerase I (Top1) generated truncated pre-rRNA fragments, which were stabilized in strains lacking TRAMP (Trf4/Trf5–Air1/Air2–Mtr4 polyadenylation complexes) or exosome degradation activities...

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Bibliografiska uppgifter
Huvudupphovsmän: El Hage, Aziz, French, Sarah L., Beyer, Ann L., Tollervey, David
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2010
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904944/
https://ncbi.nlm.nih.gov/pubmed/20634320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.573310
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