Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes.

Treatment of HeLa cells with a DNA topoisomerase I-specific inhibitor, camptothecin, results in rapid cessation of the synthesis of the 45S rRNA precursor. The inhibition of rRNA synthesis is reversible following drug removal and correlates with the presence of camptothecin-trapped topoisomerase I-D...

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Argitaratua izan da:	Proc Natl Acad Sci U S A
Egile Nagusiak:	Zhang, H, Wang, J C, Liu, L F
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	National Academy of Sciences 1988
Gaiak:	Research Article
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279701/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2829214/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.4.1060
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