Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes.

Treatment of HeLa cells with a DNA topoisomerase I-specific inhibitor, camptothecin, results in rapid cessation of the synthesis of the 45S rRNA precursor. The inhibition of rRNA synthesis is reversible following drug removal and correlates with the presence of camptothecin-trapped topoisomerase I-D...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Zhang, H, Wang, J C, Liu, L F
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1988
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279701/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2829214/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.4.1060
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