Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes.
Treatment of HeLa cells with a DNA topoisomerase I-specific inhibitor, camptothecin, results in rapid cessation of the synthesis of the 45S rRNA precursor. The inhibition of rRNA synthesis is reversible following drug removal and correlates with the presence of camptothecin-trapped topoisomerase I-D...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
1988
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279701/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2829214/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.4.1060 |
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