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Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes.

Treatment of HeLa cells with a DNA topoisomerase I-specific inhibitor, camptothecin, results in rapid cessation of the synthesis of the 45S rRNA precursor. The inhibition of rRNA synthesis is reversible following drug removal and correlates with the presence of camptothecin-trapped topoisomerase I-D...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Zhang, H, Wang, J C, Liu, L F
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1988
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279701/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2829214/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.4.1060
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