High density of unrepaired genomic ribonucleotides leads to Topoisomerase 1-mediated severe growth defects in absence of ribonucleotide reductase

Cellular levels of ribonucleoside triphosphates (rNTPs) are much higher than those of deoxyribonucleoside triphosphates (dNTPs), thereby influencing the frequency of incorporation of ribonucleoside monophosphates (rNMPs) by DNA polymerases (Pol) into DNA. RNase H2-initiated ribonucleotide excision r...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Cerritelli, Susana M, Iranzo, Jaime, Sharma, Sushma, Chabes, Andrei, Crouch, Robert J, Tollervey, David, El Hage, Aziz
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
Assuntos:
Genome Integrity, Repair and Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7192613/
https://ncbi.nlm.nih.gov/pubmed/32187369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa103
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