High density of unrepaired genomic ribonucleotides leads to Topoisomerase 1-mediated severe growth defects in absence of ribonucleotide reductase

Cellular levels of ribonucleoside triphosphates (rNTPs) are much higher than those of deoxyribonucleoside triphosphates (dNTPs), thereby influencing the frequency of incorporation of ribonucleoside monophosphates (rNMPs) by DNA polymerases (Pol) into DNA. RNase H2-initiated ribonucleotide excision r...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Cerritelli, Susana M, Iranzo, Jaime, Sharma, Sushma, Chabes, Andrei, Crouch, Robert J, Tollervey, David, El Hage, Aziz
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7192613/
https://ncbi.nlm.nih.gov/pubmed/32187369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa103
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