Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites

R-loops have both positive and negative impacts on chromosome functions. To identify toxic R-loops in the human genome, here, we map RNA:DNA hybrids, replication stress markers and DNA double-strand breaks (DSBs) in cells depleted for Topoisomerase I (Top1), an enzyme that relaxes DNA supercoiling a...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Promonet, Alexy, Padioleau, Ismaël, Liu, Yaqun, Sanz, Lionel, Biernacka, Anna, Schmitz, Anne-Lyne, Skrzypczak, Magdalena, Sarrazin, Amélie, Mettling, Clément, Rowicka, Maga, Ginalski, Krzysztof, Chedin, Frédéric, Chen, Chun-Long, Lin, Yea-Lih, Pasero, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414224/
https://ncbi.nlm.nih.gov/pubmed/32769985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17858-2
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados