Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites

R-loops have both positive and negative impacts on chromosome functions. To identify toxic R-loops in the human genome, here, we map RNA:DNA hybrids, replication stress markers and DNA double-strand breaks (DSBs) in cells depleted for Topoisomerase I (Top1), an enzyme that relaxes DNA supercoiling a...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Promonet, Alexy, Padioleau, Ismaël, Liu, Yaqun, Sanz, Lionel, Biernacka, Anna, Schmitz, Anne-Lyne, Skrzypczak, Magdalena, Sarrazin, Amélie, Mettling, Clément, Rowicka, Maga, Ginalski, Krzysztof, Chedin, Frédéric, Chen, Chun-Long, Lin, Yea-Lih, Pasero, Philippe
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7414224/
https://ncbi.nlm.nih.gov/pubmed/32769985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17858-2
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