Distinguishing the Roles of Topoisomerases I and II in Relief of Transcription-Induced Torsional Stress in Yeast rRNA Genes

To better understand the role of topoisomerase activity in relieving transcription-induced supercoiling, yeast genes encoding rRNA were visualized in cells deficient for either or both of the two major topoisomerases. In the absence of both topoisomerase I (Top1) and topoisomerase II (Top2) activity...

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Hauptverfasser: French, Sarah L., Sikes, Martha L., Hontz, Robert D., Osheim, Yvonne N., Lambert, Tashima E., El Hage, Aziz, Smith, Mitchell M., Tollervey, David, Smith, Jeffrey S., Beyer, Ann L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2011
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028620/
https://ncbi.nlm.nih.gov/pubmed/21098118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00589-10
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