p21 promotes oncolytic adenoviral activity in ovarian cancer and is a potential biomarker

The oncolytic adenovirus dl922-947 replicates selectively within and lyses cells with a dysregulated Rb pathway, a finding seen in > 90% human cancers. dl922-947 is more potent than wild type adenovirus and the E1B-deletion mutant dl1520 (Onyx-015). We wished to determine which host cell factors...

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Hauptverfasser: Flak, Magdalena B, Connell, Claire M, Chelala, Claude, Archibald, Kyra, Salako, Michael A, Pirlo, Katrina J, Lockley, Michelle, Wheatley, Sally P, Balkwill, Frances R, McNeish, Iain A
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904726/
https://ncbi.nlm.nih.gov/pubmed/20598155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-175
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