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Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin
γ-Secretase, a multi-subunit transmembrane protease comprised of presenilin, nicastrin, presenilin enhancer 2, and anterior pharynx-defective 1, participates in the regulated intramembrane proteolysis of Type I membrane proteins including the amyloid precursor protein (APP). Although Aph-1 is though...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2904414/ https://ncbi.nlm.nih.gov/pubmed/20382452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2009.12.028 |
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