Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and β-catenin signaling

BACKGROUND: Drug resistance is the outcome of multiple-gene interactions in cancer cells under stress of anticancer agents. MDR1 overexpression is most commonly detected in drug-resistant cancers and accompanied with other gene alterations including enhanced glucosylceramide synthase (GCS). MDR1 enc...

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Hauptverfasser: Liu, Yong-Yu, Gupta, Vineet, Patwardhan, Gauri A, Bhinge, Kaustubh, Zhao, Yunfeng, Bao, Jianxiong, Mehendale, Harihara, Cabot, Myles C, Li, Yu-Teh, Jazwinski, S Michal
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903501/
https://ncbi.nlm.nih.gov/pubmed/20540746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-145
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