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Ceramide and glucosylceramide upregulate expression of the multidrug resistance gene MDR1 in cancer cells
In the present study we used human breast cancer cell lines to assess the influence of ceramide and glucosylceramide (GC) on expression of MDR1, the multidrug resistance gene that codes for P-glycoprotein (P-gp), because GC has been shown to be a substrate for P-gp. Acute exposure (72 h) to C8-ceram...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3569095/ https://ncbi.nlm.nih.gov/pubmed/18035065 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2007.09.005 |
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