Defective Mismatch Repair As a Predictive Marker for Lack of Efficacy of Fluorouracil-Based Adjuvant Therapy in Colon Cancer

PURPOSE: Prior reports have indicated that patients with colon cancer who demonstrate high-level microsatellite instability (MSI-H) or defective DNA mismatch repair (dMMR) have improved survival and receive no benefit from fluorouracil (FU) -based adjuvant therapy compared with patients who have mic...

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Detaylı Bibliyografya
Asıl Yazarlar: Sargent, Daniel J., Marsoni, Silvia, Monges, Genevieve, Thibodeau, Stephen N., Labianca, Roberto, Hamilton, Stanley R., French, Amy J., Kabat, Brian, Foster, Nathan R., Torri, Valter, Ribic, Christine, Grothey, Axel, Moore, Malcolm, Zaniboni, Alberto, Seitz, Jean-Francois, Sinicrope, Frank, Gallinger, Steven
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Clinical Oncology 2010
Konular:
Original Reports
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903323/
https://ncbi.nlm.nih.gov/pubmed/20498393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.27.1825
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