DNA Mismatch Repair Status and Colon Cancer Recurrence and Survival in Clinical Trials of 5-Fluorouracil-Based Adjuvant Therapy

BACKGROUND: Approximately 15% of colorectal cancers develop because of defective function of the DNA mismatch repair (MMR) system. We determined the association of MMR status with colon cancer recurrence and examined the impact of 5-fluorouracil (FU)-based adjuvant therapy on recurrence variables. M...

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Main Authors: Sinicrope, Frank A., Foster, Nathan R., Thibodeau, Stephen N., Marsoni, Silvia, Monges, Genevieve, Labianca, Roberto, Yothers, Greg, Allegra, Carmen, Moore, Malcolm J., Gallinger, Steven, Sargent, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3110173/
https://ncbi.nlm.nih.gov/pubmed/21597022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djr153
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