Defective Mismatch Repair As a Predictive Marker for Lack of Efficacy of Fluorouracil-Based Adjuvant Therapy in Colon Cancer

PURPOSE: Prior reports have indicated that patients with colon cancer who demonstrate high-level microsatellite instability (MSI-H) or defective DNA mismatch repair (dMMR) have improved survival and receive no benefit from fluorouracil (FU) -based adjuvant therapy compared with patients who have mic...

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Detalhes bibliográficos
Main Authors: Sargent, Daniel J., Marsoni, Silvia, Monges, Genevieve, Thibodeau, Stephen N., Labianca, Roberto, Hamilton, Stanley R., French, Amy J., Kabat, Brian, Foster, Nathan R., Torri, Valter, Ribic, Christine, Grothey, Axel, Moore, Malcolm, Zaniboni, Alberto, Seitz, Jean-Francois, Sinicrope, Frank, Gallinger, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2010
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903323/
https://ncbi.nlm.nih.gov/pubmed/20498393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.27.1825
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