Defective Mismatch Repair As a Predictive Marker for Lack of Efficacy of Fluorouracil-Based Adjuvant Therapy in Colon Cancer

PURPOSE: Prior reports have indicated that patients with colon cancer who demonstrate high-level microsatellite instability (MSI-H) or defective DNA mismatch repair (dMMR) have improved survival and receive no benefit from fluorouracil (FU) -based adjuvant therapy compared with patients who have mic...

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Main Authors: Sargent, Daniel J., Marsoni, Silvia, Monges, Genevieve, Thibodeau, Stephen N., Labianca, Roberto, Hamilton, Stanley R., French, Amy J., Kabat, Brian, Foster, Nathan R., Torri, Valter, Ribic, Christine, Grothey, Axel, Moore, Malcolm, Zaniboni, Alberto, Seitz, Jean-Francois, Sinicrope, Frank, Gallinger, Steven
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Clinical Oncology 2010
Fag:
Original Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903323/
https://ncbi.nlm.nih.gov/pubmed/20498393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2009.27.1825
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