Reduced Histone Deacetylase 7 Activity Restores Function to Misfolded CFTR in Cystic Fibrosis

Chemical modulation of histone deacetylase (HDAC) activity by HDAC inhibitors (HDACi) is an increasingly important approach to modify the etiology of human disease. Loss-of-function diseases arise as a consequence of protein misfolding and degradation leading to system failures. The ΔF508 mutation i...

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Autors principals: Hutt, Darren M., Herman, David, Rodrigues, Ana P. C., Noel, Sabrina, Pilewski, Joseph M., Matteson, Jeanne, Hoch, Ben, Kellner, Wendy, Kelly, Jeffery W., Schmidt, Andre, Thomas, Philip J., Matsumura, Yoshihiro, Skach, William R., Gentzsch, Martina, Riordan, John R., Sorscher, Eric J., Okiyoneda, Tsukasa, Lukacs, Gergely L., Frizzell, Raymond A., Manning, Gerard, Gottesfeld, Joel M., Balch, William E.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901172/
https://ncbi.nlm.nih.gov/pubmed/19966789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.275
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