Rictor Phosphorylation on the THR-1135 Site Does Not Require Mammalian Target of Rapamycin Complex 2

In animal cells growth factors coordinate cell proliferation and survival by regulating the PI3K/Akt signaling pathway. Deregulation of this signaling pathway is common in a variety of human cancers. The PI3K dependent signaling kinase complex defined as mTORC2 functions as a regulatory Ser-473 kina...

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Detalhes bibliográficos
Main Authors: Boulbes, Delphine, Chen, Chien-Hung, Shaikenov, Tattym, Agarwal, Nitin K., Peterson, Timothy R., Addona, Terri A., Keshishian, Hasmik, Carr, Steven A., Magnuson, Mark A., Sabatini, David M., Sarbassov, Dos D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896829/
https://ncbi.nlm.nih.gov/pubmed/20501647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-09-0409
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