Synchronization in G(0)/G(1) enhances the mitogenic response of cells overexpressing the human insulin receptor A isoform to insulin

Evaluating mitogenic signaling specifically through the human insulin receptor (IR) is relevant for the preclinical safety assessment of developmental insulin analogs. It is known that overexpression of IR sensitizes cells to the mitogenic effects of insulin, but it is essentially unknown how mitoge...

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Main Authors: Bonnesen, Christine, Nelander, Gitte-Mai, Hansen, Bo Falck, Jensen, Pia, Krabbe, Jonas S., Jensen, Marianne B., Hegelund, Anne Charlotte, Svendsen, Jette E., Oleksiewicz, Martin B.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Netherlands 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896650/
https://ncbi.nlm.nih.gov/pubmed/19898946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10565-009-9142-x
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