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Engineering of Insulin Receptor Isoform-Selective Insulin Analogues
BACKGROUND: The insulin receptor (IR) exists in two isoforms, A and B, and the isoform expression pattern is tissue-specific. The C-terminus of the insulin B chain is important for receptor binding and has been shown to contact the IR just adjacent to the region where the A and B isoforms differ. Th...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3098868/ https://ncbi.nlm.nih.gov/pubmed/21625452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020288 |
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