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Agonism and Antagonism at the Insulin Receptor
Insulin can trigger metabolic as well as mitogenic effects, the latter being pharmaceutically undesirable. An understanding of the structure/function relationships between insulin receptor (IR) binding and mitogenic/metabolic signalling would greatly facilitate the preclinical development of new ins...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3531387/ https://ncbi.nlm.nih.gov/pubmed/23300584 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051972 |
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