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Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation
The insulin and insulin-like growth factor 1 receptors activate overlapping signalling pathways that are critical for growth, metabolism, survival and longevity. Their mechanism of ligand binding and activation displays complex allosteric properties, which no mathematical model has been able to acco...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2657531/ https://ncbi.nlm.nih.gov/pubmed/19225456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2008.78 |
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