How ligand binds to the type 1 insulin-like growth factor receptor

Human type 1 insulin-like growth factor receptor is a homodimeric receptor tyrosine kinase that signals into pathways directing normal cellular growth, differentiation and proliferation, with aberrant signalling implicated in cancer. Insulin-like growth factor binding is understood to relax conforma...

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Publicat a:Nat Commun
Autors principals: Xu, Yibin, Kong, Geoffrey K.-W., Menting, John G., Margetts, Mai B., Delaine, Carlie A., Jenkin, Lauren M., Kiselyov, Vladislav V., De Meyts, Pierre, Forbes, Briony E., Lawrence, Michael C.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826941/
https://ncbi.nlm.nih.gov/pubmed/29483580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03219-7
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