Understanding the Mechanism of Insulin and Insulin-Like Growth Factor (IGF) Receptor Activation by IGF-II

BACKGROUND: Insulin-like growth factor-II (IGF-II) promotes cell proliferation and survival and plays an important role in normal fetal development and placental function. IGF-II binds both the insulin-like growth factor receptor (IGF-1R) and insulin receptor isoform A (IR-A) with high affinity. Int...

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Bibliographic Details
Main Authors: Alvino, Clair L., Ong, Shee Chee, McNeil, Kerrie A., Delaine, Carlie, Booker, Grant W., Wallace, John C., Forbes, Briony E.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227035/
https://ncbi.nlm.nih.gov/pubmed/22140443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027488
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