Agonism and Antagonism at the Insulin Receptor

Insulin can trigger metabolic as well as mitogenic effects, the latter being pharmaceutically undesirable. An understanding of the structure/function relationships between insulin receptor (IR) binding and mitogenic/metabolic signalling would greatly facilitate the preclinical development of new ins...

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Autors principals: Knudsen, Louise, Hansen, Bo Falck, Jensen, Pia, Pedersen, Thomas Åskov, Vestergaard, Kirsten, Schäffer, Lauge, Blagoev, Blagoy, Oleksiewicz, Martin B., Kiselyov, Vladislav V., De Meyts, Pierre
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531387/
https://ncbi.nlm.nih.gov/pubmed/23300584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051972
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